Suchergebnisse

We study human trafficking in a marriage market model of prostitution. When trafficking is based on coercion, trafficking victims constitute a non-zero share of supply in any unregulated prostitution market. We ask if regulation can eradicate trafficking and restore the outcome that would arise in an unregulated market without traffickers. All existing approaches - criminalization of prostitutes (the traditional model), licensed prostitution (the Dutch model), and criminalization of johns (the Swedish model) - fail to accomplish this goal, but we show that there exists an alternative regulatory model that does. Political support for regulation hinges on the level of gender income inequality.

Hears his son, William R. Lee, is not boarding at the Commons; is William attending the Academy?

International audience ; Background. Simeprevir is approved with pegylated interferon and ribavirin (PR) for chronic hepatitis C virus (HCV) genotype (GT) 1 and GT4 infection in the USA and the European Union.Methods. This 3-year follow-up study assessed the durability of sustained virologic response (SVR) (undetectable HCV RNA 12 or 24 weeks after treatment end), and evaluated the persistence of treatment-emergent NS3/4A protease inhibitor resistance in patients not achieving SVR following treatment with simeprevir plus PR in the parent study. The maintenance of SVR after the last post-therapy follow-up visit of the parent study (LPVPS) was assessed using HCV RNA measurements. The persistence of treatment-emergent NS3 amino acid substitutions in patients with no SVR at LPVPS was assessed using population sequencing. No study medications were administered.Results. Overall, 249 patients were enrolled (200 with SVR at LPVPS; 49 with no SVR at LPVPS); 40 patients discontinued prematurely (18 with SVR; 22 with no SVR). All 200 enrolled patients who achieved SVR in the parent study maintained SVR until the last available visit in this study (median follow-up time: 35.8 months). The treatment-emergent NS3 amino acid substitutions detected at time of failure in the parent study in 43/49 enrolled patients were no longer detected in 37/43 (86.0%) at the end of this study (median follow-up time: 179.9 weeks [41.3 months]).Conclusion. This 3-year follow-up study provides evidence for the long-term durability of SVR (100%) after successful treatment with simeprevir plus PR. Treatment-emergent NS3 amino acid substitutions became undetectable in the majority of patients.Trial registration:NCT01349465; ClinicalTrials.gov.